Endocrine Abstracts

Background: Cyclical Cushing syndrome (CCS) is a rare variant of Cushing syndrome (CS) characterized by periodic cycles of cortisol excess. Diagnosis of CCS is difficult because cortisol excess occurs unpredictably and often limited to short periods. We present 2 unusual cases where the patients developed severe prolonged life-threatening “square wave” hypercortisolemic phase followed by eucortisolemia, both phases extending > 3 months. Case 1: A 75 year old male...

Objectives: The fetus is dependent on maternal thyroid hormones during pregnancy and an adequate thyroid function during pregnancy is essential for the normal brain development. The effects of subclinical hypothyroidism during pregnancy are poorly known. The present study assesses the association between thyroid hormones and thyrotropin in healthy pregnant women from the general population, and the neurodevelopment of their children at the age of 14 months.<p class="abstex...

Objective: An adequate thyroid function during pregnancy is essential for the normal brain development of the foetus, and some organochlorine compounds (OCs) can interfere with the thyroid system. The objective of the present study was to evaluate the association between exposure to some OCs and thyroid function in pregnant women from two different areas in Spain, as well as to investigate the potential confounding effect of iodine intake.Methods: Thyroi...

Introduction: Obesity is associated with an increasing risk of diabetes and atherosclerosis. Previous studies in animals show that oxidized low-density lipoprotein (Ox-LDL) can be captured by the adipocyte through different scavenger receptors (SR) and thus contribute to the worsening of insulin resistance (IR). We analyze the association between Ox-LDL levels and different SR present in adipose tissue and their relationship with the presence of obesity and insulin resistance ...